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KMID : 0363320020230020212
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Journal of Korean Oriental Internal Medicine
2002 Volume.23 No. 2 p.212 ~ p.221
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Effects of Juakium-derivative on Hematopoietic Effects
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Park Shin-Myoung
Kim Young-Chul
Lee Jang-Hoon
Woo Hong-Jung
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Abstract
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Objectives : Acording to the fact that Juakium has been frequently used in a lot of prescriptions to tonify bone marrow, We examined the hematopoietic effects of Juakium-derivative on aplastic anemia.
Methods : After C57BL/6 mice were oral administrated with Juakium-derivative and injected with benzene, we counted the number of WBC, RBC, hemoglobin, platelet, nucleated cells and other erythroid parameters and weighed the spleen. Also we measured the expression of CD34+ cell activity and analyzed the bone marrow tissue and spleen tissue histologically.
Results : The results are summerized as follow:
1. The Juakium-derivative plus benzene group showed the improvement in the number of WBC, RBC, hemoglobin. platelet, nucleated cells and other erythroid parameters, compared with the benzene only group.
2. The spleen weight and the percent of CD34+ cell of Juakium-derivative plus benzene group was higher, compared with the benzene only group.
3. The bone marrow tissue and spleen tissue of the Juakium-derivative plus benzene group showed the decrease of the infarcted area compared with the benzene only group.
Conclusions : These results suggest that Juakium-derivative has hematopoietic effects on aplastic anemia induced by benzene through increasing the blood cells and stimulating the activity of CD34+ cells. Therefore it is expected that Juakium-derivative can be used clinically to the patient with hematopoietic system disorder.
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KEYWORD
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Juakium-derivative, aplastic anemia, hematopoietic effects
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